Clinically, It is well established that the hyperchol esteremia may play an important role in the pathogenesis of atherosclerosis. And a large number of experimental reports have appeared which indicate that hypercholesteremia with lipemia would inducethe atherosclerosis in rabbits and other domestic ammals. However, the pathogenesis of atherosclerosisand the relationship between the degree of hypercholesteremia and lipoprotein changes have not yet been well elucidated .
This paper presents the changes of lipoprotein, and of some serum components, and the histopathologic changes during dietary cholesterol Induced experimental atheroscleros is in rabbits, and the relationship between the pathogenesis of cholesterol Induced atheroiclerosis and the hypercholesteremia is being discussed with following results.
1. The atherosclerotic plaques in the openings of coronary arteries and innominate artery are observed to be induced by dietary cholesterol (500 mg./dayfor- 4 weeks) after intimal injury with epinephrineInjection.
2. In the state of hypercholestermia, most o cholesterol becomes combined with the beta-lipoprotein fraction but no changes are observed in the protein moiety of beta-globulin fraction.
This results in the changes of beta/alpha lipoprotein ratio from normal range of 1.1±0.3 to over2.0.
3. A/G ratio(2.2±0.3), beta,/alpha globulin ratio(0.81+0.3). Thymol tubidity(0 unit), cepllalin-cholesterol-flocculation test(negative), and total Protein(5.6-7.3 gm./dl.) are all within normal limit during experimental process.
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